High-Containment Solutions for Antidiabetic Drug Processing
Servolift developed a fully integrated high-containment system for AstraZeneca to ensure safe and efficient processing of an antidiabetic drug. The solution covers homogenization, particle size reduction, and dosing within a closed, dust-free environment.
Key Challenge
Before compacting powder, achieving the correct particle size is critical. Our system combines controlled milling and dosing in a gravity-fed configuration known as a Milling Stack, ensuring maximum containment and operator safety.
Process Highlights
- Closed System Design:
Utilizes Intermediate Bulk Containers (IBCs) and High-Containment Split Butterfly Valves (SBVs) for dust-tight connections. - Step-by-Step Workflow:
- Source IBC Preparation: Raw material in IBC.A is lifted above the mill using a hoist column.
- Upper Containment Connection: Passive SBV on IBC.A docks with Active SBV at the mill inlet for a sealed transfer.
- Milling & Dosing: Material flows by gravity into the cone mill, where particle size is reduced and dosing is controlled via an integrated rotary valve.
- Lower Containment Connection: Milled product exits through a second SBV set into IBC.B.
- Dust-Free Disconnection: SBVs close, lock, and allow safe removal of IBCs for the next process step (e.g., blending).
- Integrated Safety:
All components—hoist, mill, SBVs—are interlocked for synchronized operation and maximum containment.
Benefits
✔ High Containment: Protects operators and product integrity.
✔ Efficient Workflow: Gravity-fed design minimizes handling.
✔ Scalable Solution: Adaptable for various pharmaceutical applications.
